Impact of training for site staff recruiting into trials of rare skin diseases: experiences from stop gap and blister

Background Nottingham Clinical Trials Unit is co-ordinating two RCTs in rare skin diseases: one recruited people with pyoderma gangrenosum (STOP GAP), the other people with bullous pemphigoid (BLISTER). Sites were initially identified via the UK Dermatology Clinical Trials Network (http://www.ukdctn.org) without using formal site selection criteria. Many sites were naive, having not recruited to trials previously. Training of site staff used a variety of methods including investigator meetings, face-to-face site initiation meetings, telephone training and remote training using a DVD. This presentation will describe recruitment and data quality by trial site, and how these relate to the type of training.